Article

Arachidonic acid modulates fluconazole-induced responses in <i>Candida albicans</i> biofilms

2025-11-26

Abstract excerpt

Candida albicans is a human commensal, which causes opportunistic infections with high morbidity and mortality and is characterised by the production of resistant biofilms. Polyunsaturated fatty acids, such as arachidonic acid, can increase azole susceptibility of C . albicans biofilms significantly. However, the underlining mechanism is not known. We investigated the effect of arachidonic acid on known fluconaz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e506aeb2-d05f-5817-b471-94e91cc9b075
DOI: 10.1101/2025.11.25.690624

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Arachidonic acid modulates fluconazole-induced responses in <i>Candida albicans</i> biofilmsDOI 10.1101/2025.11.25.690624Read

Lipidomics and <i>in Vitro</i> Azole Resistance in <i>Candida albicans</i>Semantic proximity Read

Farnesol signalling in Candida albicans – more than just communicationSemantic proximity Read

Evaluation of Differential Gene Expression in Fluconazole-Susceptible and -Resistant Isolates of <i>Candida albicans</i> by cDNA Microarray AnalysisSemantic proximity Read

Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.Semantic proximity Read

An integrated transcriptomic and metabolomic approach to investigate the heterogeneous Candida albicans biofilm phenotypeSemantic proximity Read

Alterations in the Level of Ergosterol in Candida albicans’ Plasma Membrane Correspond with Changes in Virulence and Result in Triggering Diversed Inflammatory ResponseSemantic proximity Read

Transcriptional profiling of the <i>Candida auris</i> response to exogenous farnesol exposureSemantic proximity Read

Lipid signalling in pathogenic fungiSemantic proximity Read

Genome-Wide Expression Profile Analysis Reveals Coordinately Regulated Genes Associated with Stepwise Acquisition of Azole Resistance in <i>Candida albicans</i> Clinical IsolatesSemantic proximity Read

Set1-mediated histone H3K4 methylation is required for azole induction of the ergosterol biosynthesis genes and antifungal drug resistance in <i>Candida glabrata</i>Semantic proximity Read

Upregulation of the Adhesin Gene <i>EPA1</i> Mediated by <i>PDR1</i> in Candida glabrata Leads to Enhanced Host ColonizationSemantic proximity Read

Properties and role of the quorum sensing molecule farnesol in relation to the yeast Candida albicansSemantic proximity Read