Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genetic basis of fluconazole resistance development in Candida albicans.

Biochimica et biophysica acta - 18 Jul 2002

Morschhäuser Joachim

Abstract excerpt

Infections by the opportunistic fungal pathogen Candida albicans are widely treated with the antifungal agent fluconazole that inhibits the biosynthesis of ergosterol, the major sterol in the fungal plasma membrane. The emergence of fluconazole-resistant C. albicans strains is a significant problem after long-term treatment of recurrent oropharyngeal candidiasis (OPC) in acquired immunodeficiency syndrome (AIDS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS-Related Opportunistic Infections
Share to Antifungal Agents
Share to Candida albicans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candidiasis

Share to Drug Resistance, Fungal

Share to Drug Resistance, Multiple

Share to Fluconazole

Share to Genes, MDR

Source

Identifiers

PMID: 12084466
DOI: 10.1016/s0925-4439(02)00087-x

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic basis of fluconazole resistance development in Candida albicans.PMID 12084466Read ↗

Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.Semantic proximity Read ↗

An update on antifungal targets and mechanisms of resistance in Candida albicans.Semantic proximity Read ↗

Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations.Semantic proximity Read ↗

Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.Semantic proximity Read ↗

ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates.Semantic proximity Read ↗

Molecular mechanisms associated with Fluconazole resistance in clinical Candida albicans isolates from IndiaSemantic proximity Read ↗

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal CandidiasisSemantic proximity Read ↗

The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogenSemantic proximity Read ↗

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transportersSemantic proximity Read ↗

Resistance mechanisms in clinical isolates of Candida albicans.Semantic proximity Read ↗

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virusSemantic proximity Read ↗

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazoleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.