Article
Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice.
Circulation - 5 Aug 2003
Danenberg Haim D, Szalai Alexander J, Swaminathan Rajesh V, Peng Lin, Chen Zhiping, Seifert Philip, Fay William P, Simon Daniel I, Edelman Elazer R
Abstract excerpt
BACKGROUND: C-reactive protein (CRP), an acute-phase reactant long considered merely an innocent bystander in the inflammatory process, is now recognized as a powerful predictor of cardiovascular events. Emerging in vitro evidence suggests that CRP may have direct proinflammatory and prothrombotic effects on monocytes and endothelial cells. To determine whether CRP directly modulates vascular cell function in...
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