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Article

Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.

Blood - 29 Mar 2012

Dayal Sanjana, Chauhan Anil K, Jensen Melissa, Leo Lorie, Lynch Cynthia M, Faraci Frank M, Kruger Warren D, Lentz Steven R

Abstract excerpt

Hyperhomocysteinemia confers a high risk for thrombotic vascular events, but homocysteine-lowering therapies have been ineffective in reducing the incidence of secondary vascular outcomes, raising questions regarding the role of homocysteine as a mediator of cardiovascular disease. Therefore, to determine the contribution of elevated homocysteine to thrombosis susceptibility, we studied Cbs(-/-) mice...

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Identifiers

PMID: 22186991
DOI: 10.1182/blood-2011-09-380568
PMCID: PMC3321876

Genes

CBS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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