Article
dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jun 2010
Nahm Minyeop, Kim Sungdae, Paik Sang Kyoo, Lee Mihye, Lee Seongsoo, Lee Zang Hee, Kim Jaesang, Lee Daekee, Bae Yong Chul, Lee Seungbok
Abstract excerpt
The bone morphogenetic protein (BMP) ligand Glass bottom boat (Gbb) acts as a retrograde growth signal at the Drosophila neuromuscular junction (NMJ). Endocytic regulation of presynaptic BMP receptors has been proposed to attenuate retrograde BMP signaling. However, it remains unknown whether the Gbb signal is also regulated by postsynaptic mechanisms. Here, we provide evidence that Drosophila Cdc42-interacting...
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