Article
Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulans.
Genetics - 1 Jul 2003
Fagundes Marcia R Z Kress, Fernandes Larissa, Savoldi Marcela, Harris Steven D, Goldman Maria H S, Goldman Gustavo H
Abstract excerpt
The Mre11-Rad50-Nbs1 protein complex has emerged as a central player in the human cellular DNA damage response, and recent observations suggest that these proteins are at least partially responsible for the linking of DNA damage detection to DNA repair and cell cycle checkpoint functions. Mutations in scaA(NBS1), which encodes the apparent homolog of human nibrin in Aspergillus nidulans, inhibit growth in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.