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Article

Functional characterization of W147A: a high-affinity interleukin-11 antagonist.

Endocrinology - 1 Aug 2003

Underhill-Day Nicholas, McGovern Lisa A, Karpovich Natalia, Mardon Helen J, Barton Victoria A, Heath John K

Abstract excerpt

IL-11 is a member of the gp130 family of cytokines, which signal via assembly of multisubunit receptor complexes containing at least one molecule of the transmembrane signaling receptor gp130. IL-11 forms a high-affinity complex, thereby inducing gp130-dependent signaling. Previous studies have identified three distinct receptor binding sites, I, II, and III, crucial for the binding of murine IL-11 (mIL-11) to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12865319
DOI: 10.1210/en.2002-0144
PMCID: PMC1626581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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