Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

gp130: a promising drug target for cancer therapy

7 Oct 2013

Abstract excerpt

INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes. Dysregulation of gp130 expression, activation, or associated signaling pathways are implicated in a variety of human diseases, including cancer. Accumulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to HER2/EGFR in Cancer Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24099136
DOI: 10.1517/14728222.2013.830105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

gp130: a promising drug target for cancer therapyPMID 24099136Read ↗

Understanding complex formation of gp130 cytokines for the design of selective therapeutics.Semantic proximity Read ↗

Shedding of GPP130 by PC7 and Furin: Implication in Lung Cancer ProgressionSemantic proximity Read ↗

Dissection of Signaling Cascades through gp130 In VivoSemantic proximity Read ↗

Regulation of interleukin-6 cytokine responses by mitogen activated protein kinasesSemantic proximity Read ↗

Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFcSemantic proximity Read ↗

STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant miceSemantic proximity Read ↗

Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10Semantic proximity Read ↗

Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial CellsSemantic proximity Read ↗

Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenomaSemantic proximity Read ↗

Crystal structure of a cytokine‐binding region of gp130Semantic proximity Read ↗

The cell surface glycoprotein CDCP1 in cancer—Insights, opportunities, and challengesSemantic proximity Read ↗

New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.