Article
B-cell function in canine X-linked severe combined immunodeficiency.
Veterinary immunology and immunopathology - 30 Jun 2000
Hartnett B J, Somberg R L, Krakowka S, Ochs H D, HogenEsch H, Moore P F, Weinberg K I, Felsburg P J
Abstract excerpt
Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common gamma (gammac) subunit of the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors and has a similar clinical phenotype to human XSCID. We have previously shown that the block in T-cell development is more profound in XSCID dogs than in genetically engineered gamma c-deficient mice. In this study we evaluated the B-cell function in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.