Article
Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations.
Blood - 2 Jun 2011
Kuijpers Taco W, Ijspeert Hanna, van Leeuwen Ester M M, Jansen Machiel H, Hazenberg Mette D, Weijer Kees C, van Lier Rene A W, van der Burg Mirjam
Abstract excerpt
A girl presented during childhood with a single course of extensive chickenpox and moderate albeit recurrent pneumonia in the presence of idiopathic CD4+ T lymphocytopenia (ICL). Her clinical condition remained stable over the past 10 years without infections, any granulomatous disease, or autoimmunity. Immunophenotyping demonstrated strongly reduced naive T and B cells with intact proliferative capacity....
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