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Article

Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2003

Faiola Brenda, Bauer Alison K, Fuller Elizabeth S, Wong Victoria A, Pluta Linda J, Abernethy Diane J, Mangum James B, Everitt Jeffrey I, Recio Leslie

Abstract excerpt

Benzene, a carcinogen that induces chromosomal breaks, is strongly associated with leukemias in humans. Possible genetic determinants of benzene susceptibility include proteins involved in repair of benzene-induced DNA damage. The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), encoded by Prkdc, is one such protein. DNA-PKcs is involved in the nonhomologous end-joining (NHEJ) pathway of DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12857942
DOI: 10.1093/toxsci/kfg186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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