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Article

Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2003

Bauer Alison K, Faiola Brenda, Abernethy Diane J, Marchan Rosemarie, Pluta Linda J, Wong Victoria A, Gonzalez Frank J, Butterworth Byron E, Borghoff Susan J, Everitt Jeffrey I, Recio Leslie

Abstract excerpt

Enzymes involved in benzene metabolism are likely genetic determinants of benzene-induced toxicity. Polymorphisms in human microsomal epoxide hydrolase (mEH) are associated with an increased risk of developing leukemia, specifically those associated with benzene. This study was designed to investigate the importance of mEH in benzene-induced toxicity. Male and female mEH-deficient (mEH-/-) mice and background...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12655032
DOI: 10.1093/toxsci/kfg024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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