Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?

Genetics - 1 Jul 2004

de Oliveira Tulio, Salemi Marco, Gordon Michelle, Vandamme Anne-Mieke, van Rensburg Estrelita Janse, Engelbrecht Susan, Coovadia Hoosen M, Cassol Sharon

Abstract excerpt

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly apparent that radical new approaches may be required. Computational and mathematical approaches, c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Epitopes
Share to Genes, rev

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, tat

Share to Genome, Viral

Share to Likelihood Functions

Share to Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 15280222
DOI: 10.1534/genetics.103.018135
PMCID: PMC1470929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15280222-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?PMID 15280222Read ↗

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels.Semantic proximity Read ↗

Reverse vaccinology approaches to design a potent multiepitope vaccine against the HIV whole genome: immunoinformatic, bioinformatics, and molecular dynamics approachesSemantic proximity Read ↗

Design of an immunogen containing multidimensionally conserved and immunogenic parts of the HIV proteome.Semantic proximity Read ↗

Molecular and Genetic Characterization of Natural HIV-1 Tat Exon-1 Variants from North India and Their Functional ImplicationsSemantic proximity Read ↗

HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral LoadSemantic proximity Read ↗

Selection Pressure in CD8+ T-cell Epitopes in the pol Gene of HIV-1 Infected Individuals in Colombia. A Bioinformatic ApproachSemantic proximity Read ↗

Selection on the human immunodeficiency virus type 1 proteome following primary infection.Semantic proximity Read ↗

Prediction of cross‐clade HIV‐1 T‐cell epitopes using immunoinformatics analysisSemantic proximity Read ↗

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.Semantic proximity Read ↗

A naturally occurring substitution in human immunodeficiency virus Tat increases expression of the viral genome.Semantic proximity Read ↗

Patterns of amino acid conservation in human and animal immunodeficiency virusesSemantic proximity Read ↗

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.