Article
Keratin 20 helps maintain intermediate filament organization in intestinal epithelia.
Molecular biology of the cell - 1 Jul 2003
Zhou Qin, Toivola Diana M, Feng Ningguo, Greenberg Harry B, Franke Werner W, Omary M Bishr
Abstract excerpt
Of the >20 epithelial keratins, keratin 20 (K20) has an unusual distribution and is poorly studied. We began to address K20 function, by expressing human wild-type and Arg80-->His (R80H) genomic (18 kb) and cDNA K20 in cells and mice. Arg80 of K20 is conserved in most keratins, and its mutation in epidermal keratins causes several skin diseases. R80H but not wild-type K20 generates disrupted keratin filaments in...
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