The human keratins: biology and pathology

doi:10.1007/s00418-008-0435-6

Article

The human keratins: biology and pathology

6 May 2008

Abstract excerpt

The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation. About half of all keratins--including...

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