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Article

The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.

Obesity research - 1 Jul 2003

Pihlajamäki Jussi, Ylinen Mari, Karhapää Pauli, Vauhkonen Ilkka, Laakso Markku

Abstract excerpt

OBJECTIVE: Promoter polymorphisms of the tumor necrosis factor alpha (TNF-alpha) gene are associated with insulin sensitivity and BMI. We investigated whether the effect of the G-308A polymorphism of the TNF-alpha gene on insulin action depends on BMI. RESEARCH METHODS AND PROCEDURES: The effects of the G-308A polymorphism on the rates of glucose and lipid oxidation and free fatty acid (FFA) levels were studied...

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Source

Identifiers

PMID: 12855762
DOI: 10.1038/oby.2003.125

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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