Article
Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease.
Gastroenterology - 1 Feb 2002
Valenti Luca, Fracanzani Anna Ludovica, Dongiovanni Paola, Santorelli Gennaro, Branchi Adriana, Taioli Emanuela, Fiorelli Gemino, Fargion Silvia
Abstract excerpt
BACKGROUND & AIMS: Nonalcoholic fatty liver disease, which can range from fatty liver alone to nonalcoholic steatohepatitis and cirrhosis, is related to insulin resistance. Tumor necrosis factor alpha (TNF-alpha) may induce insulin resistance, and polymorphisms of its promoter have been associated with an increased release of this cytokine. We analyzed (1) the prevalence of insulin resistance, (2) the prevalence...
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