Article
Assessment of diet-induced obese rats as an obesity model by comparative functional genomics.
Obesity (Silver Spring, Md.) - 1 Apr 2008
Li Shuyu, Zhang Hong-Yan, Hu Charlie C, Lawrence Frank, Gallagher Kelly E, Surapaneni Anupama, Estrem Shawn T, Calley John N, Varga Gabor, Dow Ernst R, Chen Yanyun
Abstract excerpt
OBJECTIVE: We applied a comparative functional genomics approach to evaluate whether diet-induced obese (DIO) rats serve as an effective obesity model. METHODS AND PROCEDURES: Gene-expression profiles of epididymal fat from DIO and lean rats were generated using microarrays and compared with the...
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