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Article

In Vivo Regulation of hTERT Expression and Telomerase Activity by Androgen.

1 Aug 2003

Abstract excerpt

PURPOSE: The most effective therapy for metastatic prostate cancer is androgen deprivation. Genes activated directly or possibly even indirectly by this steroid hormone represent potential targets for anticancer therapy. One such gene may be hTERT, which encodes the catalytic subunit of telomerase. In prostate cancer cells telomerase is activated, permitting sustained proliferation. Therefore, we tested whether...

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PMID: 12853842
DOI: 10.1097/01.ju.0000074653.22766.c8

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