Article
Development of an androgen receptor-null model for identifying the initiation site for androgen stimulation of proliferation and suppression of programmed (apoptotic) death of PC-82 human prostate cancer cells.
Cancer research - 1 Aug 1998
Gao J, Isaacs J T
Abstract excerpt
Whether androgen regulates the proliferation and survival of androgen-responsive prostate cancer cells directly or indirectly via a paracrine pathway initiated in androgen receptor (AR)-expressing stromal cells is unknown. To resolve this issue, female mice heterozygous for the testicular feminiz...
Topics
- Androgens
- Animals
- Apoptosis
- Cell Division
- Collagen
- Drug Combinations
- Female
- Humans
- Laminin
- Male
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Prostatic Neoplasms
- Proteoglycans
- Receptors, Androgen
- Transplantation, Heterologous