Article
The androgen receptor: functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines.
The Journal of steroid biochemistry and molecular biology - 20 Dec 1990
Trapman J, Ris-Stalpers C, van der Korput J A, Kuiper G G, Faber P W, Romijn J C, Mulder E, Brinkmann A O
Abstract excerpt
The growth of the majority of prostate tumors is androgen-dependent, for which the presence of a functional androgen receptor is a prerequisite. Tumor growth can be inhibited by blockade of androgen receptor action. However, this inhibition is transient. To study the role of the androgen receptor in androgen-dependent and androgen-independent prostate tumor cell growth, androgen receptor mRNA expression was...
Topics
- Amino Acid Sequence
- Animals
- Biomarkers, Tumor
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Prostatic Neoplasms