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Article

Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2008

Moehren Udo, Papaioannou Maria, Reeb Christina A, Grasselli Annalisa, Nanni Simona, Asim Mohammad, Roell Daniela, Prade Ina, Farsetti Antonella, Baniahmad Aria

Abstract excerpt

Androgens play a central role in prostate development and prostate cancer proliferation. Induction of telomerase is an early event in prostate carcinogenesis and is considered as a marker for both primary tumors and metastases. Interestingly, several reports suggest that telomerase activity is regulated by androgens in vivo. Here, we show that the wild-type (WT) human androgen receptor (AR) inhibits the...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17991730
DOI: 10.1096/fj.07-9360com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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