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Article

Modifiers of the jumonji mutation downregulate cyclin D1 expression and cardiac cell proliferation.

Biochemical and biophysical research communications - 7 May 2004

Ohno Tadayuki, Nakajima Kuniko, Kojima Mizuyo, Toyoda Masashi, Takeuchi Takashi

Abstract excerpt

Cell proliferation is an important factor in various developmental processes in tissue morphogenesis, and is strictly regulated spatiotemporally. jumonji (jmj) deficient mice with a C3H/He background show hyperproliferation of cardiac myocytes and die probably of the phenotype around embryonic day 11.5. Analyses of the abnormalities revealed that repression of cyclin D1 expression by jmj is necessary for...

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PMID: 15081428
DOI: 10.1016/j.bbrc.2004.03.131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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