Article
Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
Annals of the New York Academy of Sciences - 1 Sept 2009
Nemec Petr, Goldbergova Monika Pavkova, Gatterova Jindra, Vasku Anna, Soucek Miroslav
Abstract excerpt
Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid...
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