Article
Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women.
The Journal of rheumatology - 1 Mar 2004
Padyukov Leonid, Hytönen Ann-Marie, Smolnikova Marina, Hahn-Zoric Mirjana, Nilsson Nicklas, Hanson Lars-Ake, Tarkowski Andrej, Klareskog Lars
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is a genetically complex disease with many possible phenotypes. We investigated IL10 and TNFA gene polymorphisms in a group of Swedish women and men with RA compared with healthy individuals to estimate combinations of alleles specific for the disease. METHODS: We analyzed 264 patients with RA and 286 healthy controls for biallelic single-nucleotide polymorphisms in the -308...
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