Article
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003
Nandurkar Harshal H, Layton Meredith, Laporte Jocelyn, Selan Carly, Corcoran Lisa, Caldwell Kevin K, Mochizuki Yasuhiro, Majerus Philip W, Mitchell Christina A
Abstract excerpt
Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. Mutations in myotubularin result in the human disease X-linked myotubular myopathy, characterized by persistence of muscle fibers that retain an immature phenotype. We have previously reported the identification of the 3-phosphatase adapter protein (3-PAP), a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.