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Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.

Diabetes - 1 Dec 2002

Le Fur Sophie, Le Stunff Catherine, Bougnères Pierre

Abstract excerpt

In two cohorts of 174 and 165 obese Caucasian children, we measured insulin sensitivity and genotyped insulin receptor substrate IRS-1 and IRS-2 genes for the Arg972Gly and the Asp1057Gly variants, respectively. Because IRS-1 and IRS-2 have complementary roles in insulin signaling, we classified the genotypes in three categories: those with none of the variants in IRS-1 or IRS-2, those with one variant in IRS-1...

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Source

Identifiers

PMID: 12475767
DOI: 10.2337/diabetes.51.2007.s304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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