Article
Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 1992
Thorey I S, Pedersen R A, Linney E, Oshima R G
Abstract excerpt
Insertion of a human keratin 18 (K18)-bacterial beta-galactosidase (LacZ) fusion gene into mice has led to a unique transgenic line in which expression of the transgene is subject to unusual germ line-specific, genomic imprinting effects. Fetal expression of the LacZ reporter gene depends on the gender of the transmitting parent, with appropriate expression in liver after maternal inheritance, and ectopic...
Topics
- Animals
- Base Sequence
- DNA
- Gene Expression Regulation
- Germ Cells
- Humans
- Keratins
- Methylation
- Mice
- Mice, Transgenic
- Molecular Sequence Data