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Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways

23 Dec 1997

Abstract excerpt

The efficient expression of therapeutic genes in target cells or tissues is an important component of efficient and safe gene therapy. Utilizing regulatory elements from the human cytokeratin 18 (K18) gene, including 5' genomic sequences and one of its introns, we have developed a novel expression cassette that can efficiently express reporter genes, as well as the human cystic fibrosis transmembrane conductance...

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Identifiers

PMID: 9405675
DOI: 10.1073/pnas.94.26.14695

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