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Article

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jul 2003

Bowman Janice E, Reese Jane S, Lingas Karen T, Gerson Stanton L

Abstract excerpt

Gene transduction of hematopoietic progenitors capable of reconstituting both primary and secondary recipients is an important milestone in preclinical development of gene therapy. Myeloablation conditioning prior to infusion of transduced stem cells causes significant host morbidity. In contrast, drug-resistance gene transfer utilizes judicious in vivo selection of transduced stem cells over time, reaching only...

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Source

Identifiers

PMID: 12842427
DOI: 10.1016/s1525-0016(03)00141-2

Genes

MGMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.PMID 12842427Read ↗

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