Polyphenols as Modulators of the BMP Signaling Pathway to Counter Phenotypic Transformation of Colonocytes.

Abstract excerpt

The intestinal bone morphogenetic protein (BMP) pathway counteracts the Wnt pathway, which is overactivated in 90% of colorectal cancers (CRC) due to mutations in the adenomatous polyposis coli (APC) gene. Our study aimed to identify a polyphenol that acts on the colonic BMP pathway and to evaluate its ability to mitigate the harmful effects of 4-hydroxynonenal (HNE), a dietary genotoxic molecule, on normal...

Topics

Join the communities discussing this publication.

• Aldehydes
• Bone Morphogenetic Protein 4
• Bone Morphogenetic Proteins
• Colon
• Polyphenols