Article
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2001
González-Perrett S, Kim K, Ibarra C, Damiano A E, Zotta E, Batelli M, Harris P C, Reisin I L, Arnaout M A, Cantiello H F
Abstract excerpt
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidney disease (ADPKD), whose manifestation entails the development of fluid-filled cysts in target organs. Here, we demonstrate that polycystin-2 is present in...
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