Article
Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production.
Applied and environmental microbiology - 1 Jul 2007
Nakamura Jun, Hirano Seiko, Ito Hisao, Wachi Masaaki
Abstract excerpt
Corynebacterium glutamicum is a biotin auxotroph that secretes L-glutamic acid in response to biotin limitation; this process is employed in industrial L-glutamic acid production. Fatty acid ester surfactants and penicillin also induce L-glutamic acid secretion, even in the presence of biotin. However, the mechanism of L-glutamic acid secretion remains unclear. It was recently reported that disruption of odhA,...
Topics
- Amino Acid Transport Systems
- Anti-Bacterial Agents
- Bacterial Proteins
- Corynebacterium glutamicum
- Glutamates
- Glutamic Acid
- Models, Molecular
- Mutagenesis, Insertional
- Mutation