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Article

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling.

Journal of neuroscience research - 15 Jul 2003

Uemura Kengo, Kitagawa Naoyuki, Kohno Ryuichi, Kuzuya Akira, Kageyama Takashi, Shibasaki Hiroshi, Shimohama Shun

Abstract excerpt

Presenilin 1 interacts with beta-catenin, an essential component of the Wnt signaling pathway. To elucidate the role of presenilin 1-beta-catenin interaction in neuronal differentiation, we established SH-SY5Y cells stably expressing wild-type presenilin 1, P117L mutant presenilin 1, which is lin...

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Identifiers

PMID: 12836159
DOI: 10.1002/jnr.10641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12836159-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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