Article
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Nature - 15 Oct 1998
Zhang Z, Hartmann H, Do V M, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner B A
Abstract excerpt
Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-cat...
Topics
- Adenomatous Polyposis Coli Protein
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Apoptosis
- Brain
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cytoskeletal Proteins
- Endoplasmic Reticulum
- Glycogen Synthase Kinase 3
- Golgi Apparatus
- Humans