Article
Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994.
American journal of epidemiology - 1 Jul 2003
Mitchell Laura E, Murray Jeffrey C, O'Brien Sarah, Christensen Kaare
Abstract excerpt
Previous studies suggest that the risks of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate are influenced by variation at several loci and that these loci interact with environmental factors to determine disease risk. One putative genetic risk factor for these conditions is the retinoic acid receptor alpha (RARA) locus, which is involved in cell-specific responses to...
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