Article
Newborn serum retinoic acid level is associated with variants of genes in the retinol metabolism pathway.
Pediatric research - 1 Jun 2010
Manolescu Daniel C, El-Kares Reyhan, Lakhal-Chaieb Lajmi, Montpetit Alexandre, Bhat Pangala V, Goodyer Paul
Abstract excerpt
Retinoic acid (RA) is a critical regulator of gene expression during embryonic development. In rodents, moderate maternal vitamin A deficiency leads to subtle morphogenetic defects and inactivation of RA pathway genes causes major disturbances of embryogenesis. In this study, we quantified RA in umbilical cord blood of 145 healthy full-term Caucasian infants from Montreal. Sixty seven percent of values were <10...
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