Article
Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2013
Butali Azeez, Little Julian, Chevrier Cécile, Cordier Sylvian, Steegers-Theunissen Regine, Jugessur Astanand, Oladugba Bola, Mossey Peter A
Abstract excerpt
BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analytical approach on four studies that used similar methods. METHODS: We used logistic regression to analyze the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional...
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