Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer

27 May 2003

Abstract excerpt

BACKGROUND: A small proportion of patients with colorectal carcinoma (CRC) have synchronous tumors at the time of diagnosis. A subset of sporadic CRCs display microsatellite instability (MSI) that is associated with MLH1 silencing due to promoter methylation. In the current study, the authors investigated the proportion of tumors with MSI in patients with synchronous colorectal carcinoma (SCRC) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Multiple and Secondary Primary Cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12833454
DOI: 10.1002/cncr.11445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of a preferred molecular pathway in patients with synchronous colorectal cancerPMID 12833454Read ↗

The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer.Semantic proximity Read ↗

The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancersSemantic proximity Read ↗

Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency.Semantic proximity Read ↗

Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.Semantic proximity Read ↗

Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation.Semantic proximity Read ↗

Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated AdenomasSemantic proximity Read ↗

Colorectal Cancers with the Uncommon Findings of KRAS Mutation and Microsatellite Instability.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.Semantic proximity Read ↗

Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans.Semantic proximity Read ↗

Performance of the Revised Bethesda Guidelines for Identification of Colorectal Carcinomas With a High Level of Microsatellite InstabilitySemantic proximity Read ↗

Do MSI-L sporadic colorectal tumors develop through "mild mutator pathway"?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.