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Article

Feedback inhibition by RALT controls signal output by the ErbB network.

Oncogene - 3 Jul 2003

Anastasi Sergio, Fiorentino Loredana, Fiorini Monia, Fraioli Rocco, Sala Gianluca, Castellani L, Alemà Stefano, Alimandi Maurizio, Segatto Oreste

Abstract excerpt

The ErbB-2 interacting protein receptor-associated late transducer (RALT) was previously identified as a feedback inhibitor of ErbB-2 mitogenic signals. We now report that RALT binds to ligand-activated epidermal growth factor receptor (EGFR), ErbB-4 and ErbB-2.ErbB-3 dimers. When ectopically exp...

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Source

Identifiers

PMID: 12833145
DOI: 10.1038/sj.onc.1206516

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12833145-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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