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Article

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2003

Blum David, Galas Marie-Christine, Pintor Annita, Brouillet Emmanuel, Ledent Catherine, Muller Christa E, Bantubungi Kadiombo, Galluzzo Mariangela, Gall David, Cuvelier Laetitia, Rolland Anne-Sophie, Popoli Patrizia, Schiffmann Serge N

Abstract excerpt

Reduction of A2A receptor expression is one of the earliest events occurring in both Huntington's disease (HD) patients and mice overexpressing the N-terminal part of mutated huntingtin. Interestingly, increased activity of A2A receptors has been found in striatal cells prone to degenerate in experimental models of this neurodegenerative disease. However, the role of A2A receptors in the pathogenesis of HD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12832562
PMCID: PMC6741195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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