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The Striatum Is the Most Vulnerable Region in the Brain to Mitochondrial Energy Compromise: A Hypothesis to Explain Its Specific Vulnerability

1 Mar 2000

Abstract excerpt

The striatum, together with the hippocampus, is one of the most vulnerable regions in the brain. Recently, genetic abnormalities or mutations have been linked to various neurodegenerative diseases, that is, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), etc., but the processes from genetic abnormality to the final phenotypic expression are not well understood. Disturbances in...

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PMID: 10757330
DOI: 10.1089/neu.2000.17.251

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