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Article

Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease.

Molecular and cellular neurosciences - 1 Jan 2004

Saulle Emilia, Gubellini Paolo, Picconi Barbara, Centonze Diego, Tropepi Domenicantonio, Pisani Antonio, Morari Michele, Marti Matteo, Rossi Luisa, Papa Michele, Bernardi Giorgio, Calabresi Paolo

Abstract excerpt

An impaired complex II (succinate dehydrogenase, SD) striatal mitochondrial activity is one of the prominent metabolic alterations in Huntington's disease (HD), and intoxication with 3-nitropropionic acid (3-NP), an inhibitor of mitochondrial complex II, mimics the motor abnormalities and the pat...

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Identifiers

PMID: 14962736
DOI: 10.1016/j.mcn.2003.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14962736-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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