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Article

Chromosome cohesion is regulated by a clock gene paralogue TIM-1.

Nature - 26 Jun 2003

Chan Raymond C, Chan Annette, Jeon Mili, Wu Tammy F, Pasqualone Danielle, Rougvie Ann E, Meyer Barbara J

Abstract excerpt

Faithful transmission of the genome requires that a protein complex called cohesin establishes and maintains the regulated linkage between replicated chromosomes before their segregation. Here we report the unforeseen participation of Caenorhabditis elegans TIM-1, a paralogue of the Drosophila clock protein TIMELESS, in the regulation of chromosome cohesion. Our biochemical experiments defined the C. elegans...

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Source

Identifiers

PMID: 12827206
DOI: 10.1038/nature01697

Genes

TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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