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Article

Cohesin ring gates are specialized for meiotic cell division.

Journal of molecular cell biology - 2 May 2025

Liu Yuanyuan, Liu Bohan, Zhang Ruirui, Zhu Zixuan, Zhao Li, Jiang Ruijie, Wang Yinghao, Qi Feifei, Wang Ruoxi, Zhao Huijie, Zhou Jun, Gao Jinmin

Abstract excerpt

Cohesin is a ring complex closed with structural maintenance of chromosome 1 (SMC-1), SMC-3, and a kleisin subunit, mediating sister chromatid cohesion in mitosis and meiosis. Kleisin N- and C-terminal domains interact with SMC-3 and SMC-1, forming two distinct cohesin gates. Whether these gates are specialized for mitosis and meiosis remains elusive. Here, we create Caenorhabditis elegans mutants that express...

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Topics

Meiosis
Animals
Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Cohesins
Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Caenorhabditis elegans Proteins

Chromatids

Protein Domains

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39401990
DOI: 10.1093/jmcb/mjae047
PMCID: PMC12080224

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