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Article

Cohesin variants and meiotic timing shape chromosome segregation accuracy.

Journal of genetics and genomics = Yi chuan xue bao - 1 Feb 2026

Liu Yuanyuan, Liu Bohan, Wang Shuo, Zhao Li, Li Qian, Qi Feifei, Wang Ruoxi, Zhou Jun, Gao Jinmin

Abstract excerpt

The frequency of aneuploid gamete formation increases with maternal age, yet the effects of genetic variants on meiotic chromosome segregation accuracy during aging remain poorly understood. Using the multicellular organism Caenorhabditis elegans, we investigate the impact of mutations in the conserved cohesin complex on age-associated meiotic errors. Point mutations in the head domain of the cohesin component...

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Identifiers

PMID: 40582696
DOI: 10.1016/j.jgg.2025.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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