Article
Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.
Nature structural biology - 1 Jul 2001
Hopf M, Göhring W, Ries A, Timpl R, Hohenester E
Abstract excerpt
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has...
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