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Article

Construction of a sequence motif characteristic of aminergic G protein-coupled receptors.

Protein science : a publication of the Protein Society - 1 Jul 2003

Huang Enoch S

Abstract excerpt

An approach to discover sequence patterns characteristic of ligand classes is described and applied to aminergic G protein-coupled receptors (GPCRs). Putative ligand-binding residue positions were inferred from considering three lines of evidence: conservation in the subfamily absent or underrepresented in the superfamily, any available mutation data, and the physicochemical properties of the ligand. For...

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Identifiers

PMID: 12824482
DOI: 10.1110/ps.0305603
PMCID: PMC2323918

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Source receipt: pubmed, retrieved 7 Sept 2026.

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