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Article

Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.

Journal of molecular biology - 25 Jun 2021

Gershkovich Miron Mikhailowitsch, Groß Victoria Elisabeth, Vu Oanh, Schoeder Clara Tabea, Meiler Jens, Prömel Simone, Kaiser Anette

Abstract excerpt

The neuropeptide Y (NPY) family is a peptide-activated G protein-coupled receptor system conserved across all bilaterians, and is involved in food intake, learning, and behavior. We hypothesized that comparing the NPY system in evolutionarily ancient organisms can reveal structural determinants of peptide recognition and receptor activation conserved in evolution. To test this hypothesis, we investigated the...

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Identifiers

PMID: 33865871
DOI: 10.1016/j.jmb.2021.166992
PMCID: PMC8380825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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