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Article

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies.

Journal of the Royal Society, Interface - 1 Feb 2013

Vohra Shabana, Taddese Bruck, Conner Alex C, Poyner David R, Hay Debbie L, Barwell James, Reeves Philip J, Upton Graham J G, Reynolds Christopher A

Abstract excerpt

Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A-class B alignment, and by incorporating maximum lagged correlation of entropy and hydrophobicity into a consensus score, we have been able to align receptor transmembrane...

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Identifiers

PMID: 23235263
DOI: 10.1098/rsif.2012.0846
PMCID: PMC3565703

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